孙付保

职称：教授/博导，PI

学历/学位：研究生/博士

电话：

电子邮箱：sunfubao@126.com

生物资源与生物炼制研究团队，长期从事生物资源挖掘、绿色低碳生物制造和生化技术迭代进化等方面的科研教学工作，相关课题方向：木质纤维素制糖和发酵生物燃料/生物化学品的关键技术；饲用抗生素的生物制造技术；高活性蛋白肽/氨基酸的生物制造技术。相关技术平台有：微生物诱变育种和分子改造、微生物酶定向进化、高通量筛选；植物细胞壁结构化学、活性成分分离提取、生物大分子结构分析；酶反应过程、发酵过程优化与控制等。团队成员固定成员：孙驰贺副教授、Meysam Madadi副研究员和胡芸实验师。团队近5年承担国家重点研发计划重点专项课题、国家重点研发计划国际合作专项、国家自然科学基金重点（联合）/国际合作等省部级以上科研项目20余项，以及企业委托项目10余项；授权国家发明专利10余件（含美国专利1件）；获得省部级奖励6项和江苏省“六大人才高峰”（B类）和江苏省“双创博士”人才等荣誉；团队负责人为国际杂志J Chem Technol Biotechnol编委、中国生物工程学会会员和生物质能专委会委员。

2001.9-2004.4：大连工业大学，发酵工程，硕士

2004.9-2008.9：中国科学院过程工程研究所，生物化工，博士

2009.1-2012.9：hjc356黄金城首页线路，讲师

2012.5-2019.5：hjc356黄金城首页线路 副教授，硕士生导师

2019.6-现在：hjc356黄金城首页线路教授，博士生导师

其中：

2012.5-2013.5：加拿大不列颠哥伦比亚大学(UBC)，博士后

2016.7-2016.9：明尼苏达大学(UMN)，访问学者

一、论文（论著）发表情况

部分代表性论文如下：

团队近5年以通讯或一作在Biotechnol. Adv., Chem. Eng. J., Green Chem., Energy Convers. Manage., J. Clean. Prod.等发表SCI研究论文40余篇，代表性文章如下：

2024年

[1] Salauddin Al Azad, Meysam Madadi,* Guojie Song, Chihe Sun, Fubao Sun.* New trends in microbial lipid-based biorefinery for fermentative bioenergy production from lignocellulosic biomass. Biofuel Research Journal-BRJ, 2024,11(1): 2040-2064

[2] Guojie Song, Meysam Madadi, Xianzhi Meng, Chihe Sun*, Mortaza Aghbashlo, Fubao Sun*, Arthur J. Ragauskas, Meisam Tabatabaei, Alireza Ashori*. Double in-situ lignin modification in surfactant-assisted glycerol organosolv pretreatment of sugarcane bagasse towards efficient enzymatic hydrolysis. Chemical Engineering Journal 481 (2024) 148713

[3] Chihe Sun, Hui Zhang, Meysam Madadi, Hongyan Ren, Hao Chen, Xinshu Zhuang, Xuesong Tan, Fubao Sun*. Quantitative correlation analysis between particle liquefaction and saccharification through dynamic changes of slurry rheological behavior and particle characteristics during high-solid enzymatic hydrolysis of sugarcane bagasse. Bioresource Technology, 399 (2024) 130518

[4] Guojie Song, Chihe Sun, Meysam Madadi,* Shaohua Dou, Junshu Yan, Hailin Huan, Mortaza Aghbashlo, Meisam Tabatabaei, Fubao Sun,* Alireza Ashori. Dual assistance of surfactants in glycerol organosolv pretreatment and enzymatic hydrolysis of lignocellulosic biomass for bioethanol production. Bioresource Technology 395 (2024) 130358

2023年

[5] Meysam Madadi; Mahdy Elsayed; Guojie Song; Mahmoud M. A Bakr; Yuanhang Qin; Fubao Sun. Holistic lignocellulosic biorefinery approach for dual production of bioethanol and xylonic acid coupled with efficient dye removal. Renewable and Sustainable Energy Reviews, 2023, 185: 113605 (TOP, IF 15.9, Q1)

[6] Meysam Madadi, Guojie Song, Vijai Kumar Gupta, Mortaza Aghbashloh, Chihe Sun, Fubao Sun* and Meisam Tabatabaei *. Non-catalytic proteins as promising detoxifiers in lignocellulosic biomass pretreatment: Unveiling the mechanism for enhanced enzymatic hydrolysis. Green Chemistry, 2023, 25, 7141-7156

[7] Meysam Madadi, Mahdy Elsayed, Guojie Song, Rajeev Kumar, Mohamed Mahmoud-Aly, Bikram Basak, Byong-Hun Jeon, Fubao Sun. Biphasic lignocellulose fractionation for staged production of cellulose nanofibers and reactive lignin nanospheres: A comparative study on their microstructures and effects as chitosan film reinforcing. Chemical Engineering Journal, 2023, 142881

[8] Chihe Sun, Xianzhi Meng, Fubao Sun*, Junhua Zhang, Maobing Tu, Jo-Shu Chang, Alissara Reungsang, Ao Xia, Arthur J. Ragauskas *. Advances and perspectives on mass transfer and enzymatic hydrolysis in the enzyme-mediated lignocellulosic biorefinery: A review. Biotechnology Advances 62 (2023) 108059 

[9] Meysam Madadi, Mahdy Elsayed, Fubao Sun, Jing Wang, Keikhosro Karimi, Guojie Song, Meisam Tabatabaei, Mortaza Aghbashlo. Sustainable lignocellulose fractionation by integrating p-toluenesulfonic acid/pentanol pretreatment with mannitol for efficient production of glucose, native-like lignin, and furfural. Bioresource Technology 2023, 371:128591

[10] Guojie Song, Meysam Madadi, Yun Hu, Maobing Tu, Ali Abdulkhani, Qing Zhou, Xingmei Lu, Jo-Shu Chang, Fubao Sun*. Surfactants facilitated glycerol organosolv pretreatment of lignocellulosic biomass by structural modification for co-production of fermentable sugars and highly reactive lignin. Bioresource Technology, 2023, 383: 129178

[11] Huan Chen, Chihe Sun*, Yun Hu, Changlei Xia, Fubao Sun*, Zhanying Zhang. Reaction characteristics of metal-salt coordinated deep eutectic solvents during lignocellulosic pretreatment. Journal of Environmental Chemical Engineering, 2023, 11: 109531.

[12] Chihe Sun, Guojie Song, Fubao Sun*, Yun Hu, Ezhen Zhang, Maobing Tu, Ali Abdulkhani, Pau Loke Show. Advances in organosolv modified components occurring during the organosolv pretreatment of lignocellulosic biomass. Bioresource Technology 368 (2023) 128356

2022年

[13] Meysam Madadi, Zahoor, Syed Waqas Ali Shah, Chihe Sun, Wen Wang, Sameh Samir Ali, Ahmad Khan, Muhammad Arif, Daochen Zhu. Efficient co-production of xylooligosaccharides and glucose from lignocelluloses by acid/pentanol pretreatment: Synergetic role of lignin removal and inhibitors. Bioresource Technology 365 (2022) 128171

[14] Meysam Madadi, Guojie Song, Fubao Sun*, Chihe Sun, Changlei Xia, Ezhen Zhang, Keikhosro Karimi, Maobing Tu. Positive role of non-catalytic proteins on mitigating inhibitory effects of lignin and enhancing cellulase activity in enzymatic hydrolysis: Application, mechanism, and prospective. Environmental Research 2022, 215: 114291

[15] Lingfeng Long, Yun Hu, Fubao Sun*, Wa Gao, Zhikui Hao, Heng Yin*. Advances in lytic polysaccharide monooxygenases with the cellulose-degrading auxiliary activity family 9 to facilitate cellulose degradation for biorefinery. International Journal of Biological Macromolecules. 2022, 219: 68-83

[16] Chihe Sun, Hongyan Ren, Fubao Sun*, Yun Hu, Qiangqiang Liu, Guojie Song, Ali Abdulkhani, Pau Loke Show. Glycerol organosolv pretreatment can unlock lignocellulosic biomass for production of fermentable sugars: Present situation and challenges. Bioresouce Technology, 2022, 344: 126264

[17] Meysam Madadia, Mahmoud M.A Bakr, Ali Abdulkhanic, Zahoor, Mohammad Ali Asadollahi, Chihe Sun, Fubao Sun*, Abd El-Fatah Abomohra. Insight into alleviating lignin repolymerization by carbocation scavenger for effective production of fermentable sugars from combined liquid hot water and green-liquor pretreated softwood biomass. Energy Conversion and Management, 2022, 251: 114956

[18] Meysam Madadia, Zahoor, Guojie Song, Keikhosro Karimi, Daochen Zhu, Mahdy Elsayed, Fubao Sun, Abdelfatah Abomohra. One-step lignocellulose fractionation using acid/pentanol pretreatment for enhanced fermentable sugar and reactive lignin production with efficient pentanol retrievability. Bioresource Technology,2022, 359: 127503

[19] Meysam Madadi, Mahmoud M.A Bakr, Guojie Song, Chihe Sun, Fubao Sun, Zhikui Hao, Zahoord, Abdelfatah Abomohra. Co-production of levulinic acid and lignin adsorbent from aspen wood with combination of liquid hot water and green-liquor pretreatment. Journal of Cleaner Production, 2022, 366: 132817

[20] Chihe Sun, Yun Hu, Fubao Sun*, Yahui Sun, Guojie Song, Haixing Chang*, Siriporn Lunprom. Comparison of biodiesel production using a novel porous Zn/Al/Co complex oxide prepared from different methods: Physicochemical properties, reaction kinetic and thermodynamic studies. Renewable Energy, 2022, 181: 1419-1430

2021年

[21] Lingfeng Long, Yun Hu, Le Xie, Fubao Sun*, Jinguang Hu. Constructing a bacterial cellulose-based bacterial sensors platform by enhancing cell affinity via surface-exposed carbohydrate binding module (CBM) Green Chem 2021, 23, 9600-9609

[22] Marknoah Chinenye Nwamba, Guojie Song, Fubao Sun*, Marie Rose Mukasekuru, Hongyan Ren, Qing Zhang, Tishuang Cao, Huaming Wang, Haiyan Sun, Jiong Hong. Efficiency enhancement of a new cellulase cocktail at low enzyme loading for high solid digestion of alkali catalyzed atmospheric glycerol organosolvent pre-treated sugarcane bagasse. Bioresource Technology 338 (2021) 125505

[23] Fubao Sun*, Zhe Gu, Qiuli Zhou, Haiyan Sun, Jiancheng Luo, Zhongmei Liu, Shuxian Guo, Hongyan Ren, Zhanying Zhang, Peter James Strong. Highly efficient microbial lipid synthesis from co-fermentation of enzymatic hydrolysate of sugarcane bagasse by a Trichosporon dermatis mutant. Industrial Crops & Products 171 (2021) 113975

[24] Ajeje SB, Hu Y*, Song G, Peter SB, Afful RG, Sun F, Asadollahi MA, Amiri H, Abdulkhani A and Sun H*. Thermostable cellulases / xylanases from thermophilic and hyperthermophilic microorganisms: Current perspective. Front. Bioeng. Biotechnol. 2021, 9: 794304

[25] Marknoah Chinenye Nwamba, Fubao Sun*, Marie Rose Mukasekuru, Guojie Song, Jean Damascene Harindintwali, Samaila Ajeje Boyi,Haiyan Sun. Trends and hassles in the microbial production of lactic acid from lignocellulosic biomass. Environmental Technology & Innovation 21 (2021) 101337

二、专利情况

团队近5年申报发明专利20余件（国际2件），授权发明专利10件（国际1件），部分代表性授权专利如下：

[1] Method for co-production and processing of biological energy source by oil crops. US10,907,114 B2, 2021-02-02

[2] 一种农林生物质原料浓醪水解产糖的方法. ZL 201710037261.4

[3] 一种强化农林生物质原料浓醪酶解产糖的方法. ZL2019104673484      

[4] 油料作物联产加工生物能源的方法. ZL2016112567017

[5] 一种通过分批补料半同糖化浓醪发酵纤维素乙醇的方法. ZL 201610265845.2

[6] 一种利用太湖蓝藻的新方法. ZL 201410499839.4

[7] 一种利用烟道气爆破生物质废弃物制备固体燃料的方法. ZL201410497307.7.

[8] 一种产油酵母及其应用. ZL 2020105463630

[9] 一种高价值活性寡肽的制备方法. ZL 202110651889.X

[10] 一种高效吸附脱芳的改性活性炭及其制备方法. ZL2019100851321

[11] 一种发酵法高效制备低苦味抗氧化玉米低聚肽的方法. ZL2019100787185

[12] 一种产反式-4-羟脯氨酸重组大肠杆菌的单菌落琼脂块筛选方法. ZL 201510254026.3

三、承担科研项目情况（近5年）

团队近5年承担省部级以上项目近20项和企业委托项目近10项，代表性国家项目如下：

[1] 孙付保，国家自然科学基金-区域创新发展联合基金重点支持项目（U23A20135），秸秆生物质组分高效拆解及定向转化基础研究，2024.01-2027.12;

[2] 孙付保，国家自然科学基金-国际合作研究项目(22361142705)，木质纤维素基生态环境材料深度处理印染废水的基础研究;

[3] 孙付保，国家重点研发计划-绿色生物制造专项课题（2022YFC2104601）：生物质预处理及高效水解糖化技术；

[4] 孙付保，国家自然科学基金面上项目（22278189）：甘油有机溶剂预处理木质纤维素过程中组分甘油修饰机理及其调控；

[5] Meysam Madadi，国基海外学者青年项目（22350410382），A study on the mechanism of plant proteins' amino acids for boosting enzymatic saccharification of lignocellulosic biomass

[6] 孙驰贺，国家重点研发计划-政府间国际科技创新合作重点专项课题（2021YFE0114400）：生物燃料及生物炼制中心—甘蔗渣制备生物燃料联产化学品关键技术研究；

[7] 孙付保，国家重点研发计划-政府间国际科技创新合作重点专项（2019YFE0114600）：农林生物质“三大素”的常压甘油相有效拆分及其精炼型增值转化；

[8] 孙驰贺，国家自然科学基金青年项目(52106245)：木质纤维素类生物质浓醪糖化物质传递与酶生化转化机理及特性研究

[9] 孙驰贺，中国博士后特别资助项目(2021TQ0127)：高浓纤维质原料酶解过程浆液流动与物质传递及生化反应特性

四、获奖情况（含指导学生获奖）

[1] 广西壮族自治区技术发明一等奖（2022，第2）

[2] 胡芸，孙付保. 全国大学生生命科学竞赛（2021，科学探究类）江苏赛区三等奖；

[3] 高等教育国家级教学成果二等奖（2018，第9）；

[4] 中商联科技进步一等奖（2016，第1）；

[5] 湖南省科技进步二等奖（2016，第3）；

[6] 海南省科技进步三等奖（2017，第3）；

以上资料更新时间截止：2024年4月